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Speed No Secret, Aptitude an Enigma

Continuing on the Secret Circle theme from today's Blood-Horse Pedigree Weekly Newsletter, there is certainly no question about the speed and courage possessed by this 2012 Kentucky Derby (gr. I) hopeful. Secret Circle's potential distance capacity – a weekend win in the 8½ furlong Rebel Stakes (gr. II) not withstanding – remains something of a mystery.

If our first consideration was his pedigree page, we would tend to form the conclusion that the son of Eddington (TrueNicks,SRO) is bred for the classics. But if his pedigree tells one story, his race record to date suggests another.

Guessing – and without physiological and genetic testing, guessing is the appropriate word – at the stamina potential of the U.S. dirt performer is a hazardous business. Just as pure class will allow a young horse to race farther than he or she is genetically predisposed to do early in its career against its own age, it is possible that a horse who ultimately has class at a longer distance can be trained as a younger horse to be competitive at distances much shorter than their optimal distance. In comparison with human runners, Thoroughbreds compete over a very narrow range of distances, rather than in races that extend to the extreme end of the distance spectrum. There is a tremendous variety of different combinations of biomechanics, cardiovascular and splenic capacity, muscle fiber types, neurological factors, and processes impacting the energy systems, that can have a similar performance outcome. This particularly so at the 8½-9 furlong distances, where such a tremendous proportion of top-class U.S. dirt racing takes place.

Using a human analogy from the world of track and field, in the 800m event (metric equivalent of a half mile) – which in time duration is about as long as an 8½ furlong horse race – we can look at the examples of successive Olympic champions, Alberto Juantorena and Steve Ovett. Juantorena was an extremely speedy type who won the 400m (metric equivalent of a quarter mile) and 800m (metric equivalent of a half mile), both in record times, at the 1976 Summer Olympics in Montreal. Fifth in Montreal was Steve Ovett, then an international novice. He was destined to win the 800m at Moscow Olympics in 1980, but was a very different physiological type to his predecessor. Almost three seconds slower than Juantorena at 400m – a huge margin at the international level – Ovett was also a superlative miler, won a Commonwealth Games title at 5000m (3.1 miles), and defeated an Olympic marathon runner in a half marathon. So despite their virtually equivalent performances at 800m, Juantorena and Ovett physiologically and genetically represented something totally different, and would have likely had a very different genetic impact on their offspring (in Thoroughbred terms they would have generally sired different racing types over their career).

So it is with Thoroughbreds. In our work at Performance Genetics we have come across Kentucky Derby, Belmont Stakes, and Breeders’ Cup Classic winners that have the genetic make-up that would indicate they are best as sprinters, but through a combination of superior maturity to their contemporaries (an edge that the speedier types still often hold by the first Saturday in May); pace factors; training style (and quite probably veterinary help!); have carried their speed beyond their physiologically optimal distances. This tension between Mendelian inheritance and environmental factors, and what they subsequently demonstrate on the racetrack is one of the reasons that we can have what appears to be a "route pedigree" throw up horses as fast as Secret Circle, Discreetly Mine (TrueNicks,SRO), or Midnight Lute (TrueNicks,SRO), or that a Belmont winner like Touch Gold (TrueNicks,SRO), who is genetically more like a sprinter and thus very often mismatched with mares he is sent, get runners as speedy as Midas Eyes, Mass Media (TrueNicks,SRO), or Medallist (TrueNicks,SRO).

As far as Secret Circle is concerned, as runner we’d put more faith in what we’ve seen on the track to date, than what we see on the pedigree page. Our 'guess' is that like Baffert-trained The Factor last year, he’ll ultimately mature into a sprinter/miler type, but for now he will be one of many sprinter/milers lining up on the first Saturday in May taking his shot at the Run for the Roses.

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8 Comments:

Hi Alan,

Very interesting and well thought-out piece. I'm basically with you until mid-way through your 5th (2nd to last) paragraph (begins with "So it is with thoroughbreds..."). We too often attribute our aptitude surprises (pedigree-wise) to non-genetic factors (environment/training, etc.) when in reality the cause was essentialy genetic. That pedigree analysis or (for example) your "Performance Genetics" "markers" deduced differently likely speaks more to their (our) inadequacies rather than pointing to different causes. As example, I'd posit that both Discreetly Mine and Midlight Lute owe essentially their apptitudes to their respective genomes (and while it is often far less apparent, pedigree analysis alone here offers clues by simply focusing on their dams' production). Touch Gold's racing vs sire record disparity is less readily apparent (but even here his full-sibling offers insight), but the cause most likely lies with his "genetics" -many of its mysteries remaining beyond our grasp. It's far too easy to jump to the environment, etc. (partial) causality when instead we should be chalking it up to our lack of understanding of the dynamics of genetics... The concept and use of heritability (its percentages) needs re-examination.  

sceptre 22 Mar 2012 5:29 PM

Eddington was a slow developing (first stakes win in fall of 3yo year), staying type, whose stud record has been anything but sterling. Secret Circle is from his third crop and is his first SW of any kind. In the BH Stallion Register, he has 216 starters, and one SW. Dismal. It is likely that Eddington had little to do with Secret Circle's phenotype, so extrapolating SC distance proclivities from Eddington's would be foolish. The dam's family are mainly sprinter/miler and miler types, often winners at 2 short, then milers thereafter, including the dam's half-sister Really Polish, who ran 3rd in the Ky Oaks. This seems a more likely future for Secret Circle, IMHO.

Pedigree Ann 23 Mar 2012 9:38 AM

Genetics should also be coupled w/epigenetics nowadays as so  much is known about methylation, telemeres, etc. and how offspring are affected.

peggy 23 Mar 2012 9:44 AM

Hi Sceptre,

I think to a degree, we are pretty much talking about the same thing.

If we don't know what the horse is from a biomechanical/ physiological/genomic standpoint, we are really just guessing at his optimal distance. The overall pedigree (whether one wants to look at it subjectively or to attempt some measurement, such as dosage) is often something of a guide (like does tend to beget like), especially when taken into consideration with what we've seen on the racetrack.

That said, there are times when what a horse has actually inherited is in conflict with what we might guess he would inherit. Looking at the pedigree, most people would guess that Secret Circle would have no problem with nine furlongs, and probably not with the Derby distance either. The same would probably have gone for Discreetly Mine (hey, I thought he might be a Belmont Stakes horse!).

This is nothing new by the way. Just after the war in England, we had the brilliant Tudor Minstrel, who didn't get an inch past a mile, but was by Owen Tudor (who stayed well enough to win an Ascot Gold Cup at 2 1/2 miles), out of a mare by Sansovino (Epsom Derby), out of Lady Juror (won Jockey Club Stakes at 1 1/2 miles), who in turn was by Son-in-Law, who did his best work at distances in excess of two miles.

While the combination of genotype and phenotype might regulate a runner's optimum distance (and the genotype, phenotype and cardio can be at odds with one another), there are exceptions. Both we and other researchers have seen Kentucky Derby winners that are genetically sprinters (they are the Alberto Juantorena 800m type) and often have still a maturity edge against their contemporaries in the Spring, and especially if they are sprint types that also have a big cardio. They would generally fair less well against older horses and later-maturing three-year-olds in a Breeders' Cup Classic.

I can also recall that among the good runners of the last 20 years or so that we've sampled, coming up on a horse who had the genetic profile of a sprinter, but who had some excellent route performances. A little research showed that he did best off a slow early pace, and his success was probably down to some smart training that enabled the horse to conserve his anaerobic power to the closing stages of the race, and thus ended up being a grade one route horse, rather than perhaps a grade two or three sprinter miler.

Alan Porter 23 Mar 2012 9:53 AM

Hi Peggy,

I think you are spot on with the reference to epigenetics, but it might be sometime before we have a really handle on that, as we're only just starting to come to terms with the mechanics of the genetics of performance!

Alan Porter 23 Mar 2012 11:49 AM

Thanks, Alan. Yes, I'm basically with you. I did, however, cringe at your statement "Both we and researchers have seen Kentucky Derby winners that are genetically sprinters..." Since one of my points suggested that our knowledge of genetics is too inadequate to accurately identify (genetically) aptitude, you, by this statement, appear to believe otherwise...Your points about the exceptions (ex.-Tudor Minstrel) are very interesting. Graustark, particularly when viewed retrospectively, is perhaps another worth pondering. He was not bred to be a sprinter, but flashed brilliant sprinter speed. He did demonstrate an ability to stretch that speed at least to 1 1/16 m, and lost (by a nose) his only (and last) start at 1 1/8 m while fracturing a coffin bone. He was the odds-on favorite for that year's Derby, but was retired after that Blue Grass. He went on to sire mostly classic staying types of quality. It's quite rare for a horse to display such speed and also stay classic distances-as perhaps, what did prevent Tudor Minstrel. You mentioned the potentiality of competing (my word) attributes (Genotype-Phenotype-Cardio-Muscle fiber type predominance-Respiratory, etc.). Had a Tudor Minstrel sired more stayers (he didn't sire only sprinters, but unlike Graustark did sire some brilliant sprinters-Tumiga comes readily to mind-but then there was also the more classic, What A Treat), the competing attributes hypothesis might have fitted him. In the case of Graustark it may have applied. Problem is, we don't know how far Graustark might have stretched-but one might surmise that he had a goodly number of fast twitch fibers combined with a quite good cardio-respiratory and a physique phenotype akin to a muscular stayer (a bit rare) variety. Some of this would make sense, in view of his later sire record, but I've always been mystified why he didn't sire more speed. And also, think back, name another son of Ribot with speed anywhere approaching Graustark's (Yes, I know about the rumors-that he was actually sired by Swaps- but Olin Gentry and I were very close, and he swore to me that Graustark was sired by Ribot-also, take a look at the Darby Dan mares bred to Graustark-several were by Swaps)... Putting it together, I think you've already hinted at, at least, some of the reasons. You, yourself, are a runner, and are aware that if you go out too fast you'll have nothing left well before the end-even though at most other times (with the proper pace) you may be well capable of succeeding at relatively long distances. So, along with the aforesaid competing attributes, there is also the mental (inherited and/or acquired) "qualities" at play. Maybe a Tudor Minstrel, a Graustark, or let's say a Raise A Native had a "negative mental" to mitigate against their relative positive stamina attributes?  

sceptre 23 Mar 2012 7:22 PM

Hi Sceptre,

Lots of interesting things in that reply! As a runner, I've discovered that I'm a type - good V02 max, but a lot of fast-twitch, so when I race anything from a mile to 5k, I'm better running three-quarters of it steady then hammering the last quarter. If I go out too fast, you need a dust-pan and brush to pick me up! I guess if I'd have got good enough to go to stud, I might have sired a variety of types!

The cases of pretty quick horses that don't sire a lot of speed are interesting. One in Europe was Brigadier Gerard who was a brilliant miler, who stayed 10 furlongs, and gutted out a win in the King George VI & Queen Elizabeth II Stakes. He wasn't a very good sire, but even his good ones didn't show a ton of speed.

With regard to genetically identifying aptitude, while there again, is obviously an inter-reaction with other aspects (for example a biomechanically highly efficient horse, with a great cardio is more likely to stretch his speed than one who has an energy wasteful motion, and more modest cardio) we do think that we have a good genetic model which is particularly accurate at identifying high-class speed horses (and doesn't involve a so-called "speed gene."). This would be with regard to optimal distances for a mature horse, so doesn't take into account class differentials, maturity advantages (which come into play in the Kentucky Derby) or pace scenarios. So, while we do feel we are very able to spot a horse that is an elite sprinter/miler type, it's no surprise to us when an exceptional version of that type, blessed with very good cardio, can win a Kentucky Derby. To use another athletic analogy, Sir Roger Bannister, the first man to break 4:00 mins for a mile, says optimal distance was 1000m (5/8ths of a mile) - a trip over which he broke the world-record in a private time-trial - but is not contest in international championships. However, he was not only able to set a world record for a mile, but also defeat John Landy, the man who had taken his mile record, in that epic Commonwealth Games battle.

I think there is a mental component too, with regard to "will to win" and ability to harness speed. A South African physiologist, Dr. Tim Noakes, has advanced "The Central Governor" theory - that basically the body sends signals to the brain saying it is in a degree of crisis, and the brain, wishing to restore homeostasis, says "slow down." It's probably why runners - who obviously know the distance of their event before they start - can generally accelerate near the finish, which wouldn't be possible if pure physical factors were restricting pace.

With a human, there are obviously more abstract external motivations than with a horse, but it would be no surprise if the willingness to over-ride "the central governor" or a different set-point for it is somewhat hereditary (we actually have an article on the subject at the Performance Genetics web-site performancegenetics.com/.../the-will-to-win).  Dr. Steven Tammariello, Performance Genetics' Lead Geneticist, has done some work on temperament and suitability for various equine disciplines, and has found some genetic factors.

I think overall, we're very much in the same place, where the difference is just a question of some subjective interpretation of what we see, and the multitude of different ways of getting the the same physical performance.

Alan Porter 24 Mar 2012 10:37 AM

Thanks, Alan; your post was quite helpful. Also, I'm now less skeptical of your Performancegenetics.

sceptre 25 Mar 2012 6:10 PM

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